Integrative bioinformatics for system biological modelling of the genotype-phenotype-depiction in farm animals
CP coordinator: Prof. Norbert Reinsch, FBN Dummerstorf Aims: - Construction of an “Animal-Trait Ontology” (ATO)-platform focused on behavioural characteristics,
- Establishment of an ontology-based central database for the PHENOMICS-consortium (FarmPheno),
- Expansion of the bioinformatic-pipeline to evaluate high-efficiency-information of diverse leveled gene
expression and adaption to cattle and pig, - Development of statistic processes to include a modelling of genotype-phenotype-depiction of biosignatures,
- Bioinformatic pipeline to evaluate high-efficiency-information of diverse leveled gene expression and adaption to cattle and pig,
- Development of adaptive tests to analyse SNP gene expression associations,
- Validation and approvement in praxis-relevant population (CP4) of the candidate signatures developed by
the CP3-data. |
Sub-projects |
Sub-project 1.1: 'Animal Trait Ontology' – characteristics-ontology for the fields of behaviour and welfare and project database
Project leader: Prof. Norbert Reinsch, FBN Dummerstorf
Sub-project 1.2: Bioinformatic pipeline to integrate high-efficiency-information and geno-/phenotypical parameters in network and PNFL system modells for cattle and pig
Project leader: Prof. Ralf Zimmer, LMU München
Sub-project 1.3: statistical analyses of associations between single nucleotide polymorphisms and gene expressions
Project leader: Prof. Andreas Ziegler, CAU Kiel
Sub-project 1.4: Derivative of biosignatures by utilisation of network-topological a-priori information and profiles of diverse levels of gene expression
Project leader: Dr. Dirk Repsilber, FBN Dummerstorf |
